Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Role of Endorphins in Alcohol Dependency: What You Need to Know
Bruce Rose Published on: 18/09/2025
Endorphins are naturally occurring chemicals in the brain that help us manage pain and boost pleasure. Often called the body’s “natural opioids”, they are released during activities like exercise, laughing, eating, and social bonding. When endorphins flood the brain, we feel good — relaxed, happy, or even euphoric.
The Sinclair Method (TSM)
Can I Get Naltrexone from My GP? What You Need to Know
Bruce Rose Published on: 17/09/2025
Naltrexone is a powerful tool for reducing alcohol cravings, especially when used as part of the Sinclair Method (TSM). But if you’re considering this approach, a key question often arises: Can I get Naltrexone from my GP?
The Sinclair Method (TSM)
Ozempic vs Naltrexone: Understanding the Key Differences for Alcohol Recovery
Bruce Rose Published on: 16/09/2025
Ozempic and naltrexone are very different medications, each targeting distinct areas of the brain and body. Ozempic is designed to manage type 2 diabetes and promote weight loss by reducing hunger. Naltrexone is specifically designed to reduce cravings and the rewarding effects of alcohol.
The Sinclair Method (TSM)
The Sinclair Method vs Abstinence: Which Path to Recovery is Right for You?
Bruce Rose Published on: 15/09/2025
When we talk about recovery from alcohol use disorder (AUD), most people still think of abstinence — the complete and permanent cessation of drinking. It's the traditional approach taken by many rehab centres and support groups like Alcoholics Anonymous.
The Sinclair Method (TSM)
Gradual Reduction with The Sinclair Method: Why It Works
Bruce Rose Published on: 11/09/2025
That’s where The Sinclair Method (TSM) shines. This innovative approach offers an alternative: gradual reduction, using the medication naltrexone to change your brain’s response to alcohol, one drink at a time.
The Sinclair Method (TSM)
The Importance of a Support Programme Alongside The Sinclair Method
Bruce Rose Published on: 10/09/2025
The Sinclair Method (TSM) has emerged as a ground-breaking approach to reducing alcohol consumption through a medication-first strategy. By using Naltrexone to disrupt the brain’s reward cycle, it gradually helps people lose interest in alcohol.
The Sinclair Method (TSM)
